After our FET that just failed, we have been stuck with over a thousand dollars worth of unused meds. It makes me sick to see them so I have stashed them away in my closet for the time being. Throwing them in the trash also makes me somewhat sick considering they were so darn expensive. Yes, I know I could donate them, and as a last resort I am sure I will, but I would like to somehow justify the costs in my mind after spending a small fortune on assisted reproduction the past 6 years, all of which was not covered by insurance at all. Even recouping a small amount for them would be satisfying.
I have 4 boxes of unopened Crinone (quite possibly the most expensive drug on the planet) that do not expire for several years. I also have unopened Progesterone in Oil, DelEstrogen, & Estrace. If a fellow blogger out there needs any of these expensive IVF meds, I would be willing to discount them significantly. Feel free to comment or email me at email@example.com
Okay ladies! Its time for you to give me all the tips you have on intramuscular injections like PIO and Del Estrogen. I know if anyone has the best kept secrets its you all! Most doctors and nurses havent had those shots injected into their own ass, and although they give valuable tips, they are just not as valuable as yours Im sure. Experience is everything here!
I did notice that my calendar says to do the PIO shots in the a.m. Im not sure why and need to ask. Anyone else had the same? Might be an issue in the morning with mine and hubbys schedule if he has to do them for me. Anyone out there do their own PIO or Del injections? I must admit I did my own ass trigger shot because I hated the idea of someone else doing it for me. Although I pulled it off, it wasnt easy to do by any means.
Until the Lupron Depot shots Ive had the past few months, no one had ever injected me in the butt. Lol. Id much rather do my own shots, but I have a feeling its not going to be possible with these two. Can I do them myself? And what about heat, ice, position, etc.? Please inform!
Keep in mind I have never done either of these two intramuscular injections before (just the trigger) so no info will be silly to me. All will be considered and appreciated. I have only done Crinone with Vivelle/Estrace for my prior 3 transfers. Im thinking I will have my nurse mark the areas to aim for with a marker before I do the first one on my own?
Thanks in advance for taking the time to educate me in this area!
All of our goodies arrived via overnight this a.m. We gave each other the look when the doorbell rang and we received the box.
The conversation that followed went something like this-
Me: Do you want to open it now?
Him: Sure! Im excited, are you?
Me: Sort of, but Im nervous too. Maybe we should wait to open it.
Me: Nevermind, lets open it now. Will you open it?
Him: Alright (starts opening it)
Hubs went through the prescription list, checking off each item as I pulled them out of the box. Everything was correct!
I cant believe we are doing this again. And with all these needles this time (so huge they are!). Ill be good though, not too worried about the needles. After I get over the initial injections, it will be fine.
I just want this all to work! I start my meds tomorrow, so today I will enjoy our last day/night pre-cycle, which might include some wine!
As promised, this post details our first IVF from the “stim” start to the pregnancy test.
Our goal is to share our experiences to those who are thinking of doing IVF, getting ready to do IVF, or have a friend or family member going through IVF.
Although every individual’s journey is different, we hope that this can provide you with some general insight on what to expect. When we began IVF, we had a lot of these questions ourselves.
How often I went to the doctor for monitoring
Since we knew I would be going to the fertility practice a lot once our “stim” began (before egg retrieval, when you are pumping up your body to produce a zillion follicles that will hopefully produce nice, mature eggs), we arranged to start it over my Spring Break (teacher perk) so I didn’t miss work. And if I felt lousy, I could relax at home.
Our stim was 10 days total. Here are the days I went in for blood & an ultrasound, with my estradiol (fancy for estrogen) levels and follicle amounts (future eggs):
Stim Day 1-estradiol level 18
Stim Day 4-estradiol level 211; 16 follicles
Stim Day 6-estradiol level 744: 18 follicles
Stim Day 8-estradiol level 1556: 20 follicles
Stim Day 10 (trigger day!)-estradiol level 2619; 22 follicles
NOTE: It is important monitor the estrogen levels frequently because if they get too high, you can hyper-stimulate. My doctor never wanted to see these levels rise much above the 3000 mark before retrieval to prevent hyperstim. Many doctors will cancel the cycle before the trigger shot/retrieval if the levels are too high (we knew someone personally this happened to).
The doctor told us that our stim was textbook perfect! We were soooo happy since this was one of our worries. My body was reacting fine to the meds and we were moving on to the retrieval on day 12.
The medications I was prescribed during “stim”
Follistim– 150 units once daily into stomach, rotating sides. Easy injection, must be refrigerated. Tip: Take it out of the fridge about 15 minutes before so the liquid isn’t so cold when injecting! Be sure to do this injection at the same time each day.
Menopur-75 units once daily into stomach, rotating sides. This one stings a little & is a pain in the you know what because it doesn’t come ready. You have to mix it! Unreal for the amount of money you are paying right?! I think a nurse should come with the meds for the cost. LOL. We messed up the mixing once and I cried (those tears we talked about in prior post). Thankfully, if you mess up, there will be (a little) extra of the meds, so don’t worry too much.
Pregnyl “Trigger” shot-this injection is done only 1 time which is 36 hours before the egg retrieval. For me, it was on day 10 of my stim. It is different for every woman based on how follicles are maturing when the ultrasounds are done. I won’t lie, this shot royally sucks. It is an intramuscular injection, unlike the Follistim & Menopur which are subcutaneous injections (right beneath the skin). They tell you to have your husband do this injection because it needs to be in the a*** in a specific spot. Initially, I thought I would have him do my injections for me. When it came down to it, I would grab the needle from him. Don’t ask me why, but I was more scared to have him do it than do it myself. So, needless to say, I injected the Pregnyl & it hurt!
Prenatal vitamin/Folic acid/Baby aspirin 1x per day
Doxycycline- antibiotic to start the night before the egg retrieval and 2 days following
The medications I was prescribed after the retrieval until the day of the pregnancy test (if pregnant, continue Estrace, Crinone, Prenatals, Folic Acid, & Baby Aspirin until out of 1st trimester!)
Medrol-oral 4x per day, for 4 days after retrieval
Estrace-oral or vaginal pill 2x per day, this is estrogen
Crinone-vaginal suppository 2x per day (Yucky!), this is progesterone
Prenatal vitamin/Folic acid/Baby aspirin 1x per day
It was finally the end of March (remember we started birth control in February). We couldn’t believe we made it to this day! This is a big step for an infertile. With IVF, you have to remember that anything can go wrong at any given time. So we were elated nothing had gone wrong…yet.
I remember feeling so ready to get those eggs out of me by the time the morning of the retrieval rolled around. I literally felt like a goose ready to lay a bunch of eggs LOL. Totally bloated. Surprisingly, I wasn’t that nervous, just a little thirsty since I hadn’t eaten or drank since the night before.
When we arrived, my husband was taken to the “man room” to do the most important count ever. I could tell he was pretty nervous. Maybe that is why I wasn’t. I knew if I was, it would make it worse for him, especially since he is usually so calm. Turns out, all went well with Shane’s count; it was the highest it had ever been. Still low, but definitely an improvement.
He couldn’t be in the room during the retrieval, just the doctor, RN, & anesthesiologist. Once I was prepped and in the surgery room, the doctor showed me a tiny window pass through where the embryologist (and the sperm) wait for the eggs to be handed off to her immediately after they are retrieved. We elected to do ICSI along with IVF (where the embryologist chooses the bests sperm and injects them into the eggs).
I chose to be under general anesthesia for my egg retrieval rather than localized, or twilight anesthesia. General anesthesia costs more, but it was worth it to me. When speaking with fellow IVF’ers, many told me the retrieval was the worst part of the process. Maybe. When I woke up from the retrieval, we were informed that everything went perfect again! Another BIG step. We had heard horror stories of no eggs being retrieved and were scared to death it might happen to us. We had 19 eggs retrieved. Woohoo!! The doctor seemed really happy & told us we would hear from the embryologist the following day.
The Days Following the Retrieval
Now we were biting our nails on whether or not any of these eggs and sperm would actually form embryos. Remember, I told you it’s 1 worry at a time while you are breathing, sleeping, and eating IVF.
The embryologist called us the next day and told us that overnight:
18 eggs were inseminated via ICSI
Of the 19, 13 fertilized normally with Shane’s sperm, forming embryos
More fantastic news! The embryologist would continue to be in touch with us over the next few days so we knew when we would be transferring. In IVF, supposedly the longer the embryo grows, the better. Why? It is like survival of the fittest. The best embryos make it and the others usually don’t.
Day 3 after the retrieval we learned that:
5 of the 13 embryos were no longer viable
8 of these embryos were still viable and growing 🙂
Again, we were very pleased with the news. However, the next few days I began to be a nervous wreck. What if all of the remaining embryos die off like the 5 others did??? I was reassured it wouldn’t happen. No one can assure you of anything during IVF.
Day 5 following the transfer we were informed that:
Our 8 embryos were still viable! Thank God.
The embryos were graded as follows:
3 embryos were 6AA (best grade you can get…hooray!!!)
2 embryos were 6AB (second best)
3 embryos were 6BC (not the best)
TRANSFER DAY WAS SET FOR TOMORROW!!
We welcomed the month of April 2014. This is was the day/month we had been waiting for for years! Our transfer was 6 days post retrieval, the latest a transfer can be done before the embryos must be frozen. Many people have transfers as early as 2 or 3 days after their retrieval, depending on how well the embryos are doing. Since this was our first IVF, and our embryos were graded great, we decided to transfer only one 6AA embryo.
The actual transfer itself is a piece of cake compared to the rest of what has been going on (it only takes about 5 minutes). You get there about 30 minutes prior and they prep you. You need to have a full bladder for the transfer so the uterine cavity is able to be clearly seen on ultrasound. This was hard for me because I have a really small bladder to begin with! If you are in the same boat as me, you can ask them to fill your bladder for you (I learned this on IVF #2) right before they transfer the embryo. This way you don’t even worry about drinking & miserably holding it. After the transfer, they will drain it for you while you rest. Ahhhhh.
Good news-this time hubbie gets to be in the room with you, and you are awake!! He sat by me & held my hand the whole time. We were in the same room as for our retrieval so the embryologist can access the room with the embryo when the doctor is ready. The embryologist actually comes in with a picture of the embryo before the transfer and discusses it with you. Again, all was going very well. I was starting to think maybe this wasn’t too bad after all!
Then the RN begins by doing an abdominal ultrasound to make sure the bladder is full & the uterine cavity is clear. If this looks good, the doctor cleans out the cervix since you have been sticking that gooey Crinone (progesterone) up there for a week now! Ughh. My doctor always plays music during transfers. Hey, whatever floats your boat I guess. The lights are dimmed so it is actually more of a relaxing atmosphere than you would think.
She then inserts a catheter (painless) into the uterus, and what’s nice is that you are seeing all of this take place on the ultrasound screen right next to you. After the doctor makes sure the catheter is in the right place, she calls for the embryologist to bring the embryo in. It feels like an eternity for this to happen. Literally. The embryologist brings the embryo in a catheter that fits into the doctors catheter. You are praying that they both have very steady hands. You start thinking what if they drop the catheter? What if they insert it in the wrong place? Dear God.
The doctor releases the embryo and you actually see what appears to be a little white dot on the screen in your uterus! Super cool. It could be your future baby! After the embryo is in the uterus, you rest there for about 30 minutes. I make my hubs tell me jokes so I can laugh. It’s good for the soul right?
Before we left, the doctor explained that everything went perfectly with the transfer. Another step in the process accomplished. We set the date of the blood test to see if we were pregnant for exactly 10 days later. Yes, this my friends is what is called the excruciating 2 WEEK WAIT (even though it’s not really 2 weeks, it feels like 4, so it’s earned its name for sure).
The next 48 hours are strict bed rest (missing more work for sure). A lot of doctors aren’t big on bed rest, but mine happens to be. If yours is too, make sure you have some movies, books, and good food of course. We watched Frozen and I started reading Wild. My hubs made sure I was off my feet and pampered me. It was nice.
Then the new phase of worrying began. I can’t lie, the next 8 days were difficult mentally. Anyone who has been through IUI or IVF knows this. We both went back to work and tried to keep our mind off it. Thankfully, I had state testing going on at school so that kept me somewhat focused. But the thought of what if it didn’t work kept creeping into my mind. It’s pretty consuming.
Day 6 post transfer we decided to go out to dinner with our family. It was a Friday night, and my aunt & uncle were in town. I remember sitting across the table from my mom and I could smell her wine. A little later, my hubs came back from the bathroom and I could smell the soap on his hands. I felt off. That’s when I knew it had actually worked. I was pregnant; for now.